Neurocritical Care Neurologist, University of Minnesota

Position:
Neurointensivist
Specialty:
Neurology - Neurocritical Care, Neurology - Research, Critical Care - Neurology
Location:
Minneapolis, Minnesota

The Department of Neurology at the University of Minnesota (U of M) seeks a board eligible Neurologist with advanced training in Neurocritical Care to join the faculty during a time of exciting growth. Protected time for research and leadership opportunities will be available for qualified individuals. J1 and H1b visas are available for candidates needing sponsorship. Additionally, tenure and non-tenure track faculty appointments are available based on interests and qualifications. The U of M program is comprised of internationally known stroke specialists and neurointensivists, as well as interventionalists who have pioneered several endovascular techniques, collectively representing the only comprehensive stroke center of its sort within the Twin Cities’ catchment population of 3.8 million.

Leadership

Chairman, Department of Neurology

Director of Neurocritical Care

Stroke Program Director 

The Division of Stroke and Neurocritical Care boasts one of the top clinical and research programs in the country based on several distinguishing attributes, including:

  • 3 ACGME-Accredited Cerebrovascular Fellowship Programs
  • NINDS Research Funding & StrokeNet Research Center
  • Leader in NIH Funding
  • Cutting-Edge Neuroscience Research
  • Commitment to Academic Values and Protected Time

 

Neurocritical Care and Vascular Neurology at the U of M

The Neurocritical Care Service is part of the Stroke Center at the University of Minnesota. The Stroke Center is an interdepartmental and inter-institutional program organized to build collaboration in the areas of service, education and research in cerebrovascular disease between the departments of Neurology, Neurosurgery and Radiology. Candidates will join a team of physicians practicing vascular neurology, Neurocritical care, and neurointerventions from neurology, neurosurgery and radiology. The program is currently engaged in high quality clinical and basic science research, as well as active fellowships in vascular neurology, Neurocritical care and endovascular surgical neuroradiology.

Among the significant strengths of the program are the range and depth of the clinical experience provided at several teaching hospitals (Hennepin County Medical Center and University of Minnesota Medical Center-Fairview for the Vascular Neurology program); the devotion of the full-time faculty at each of these hospitals to teaching, patient care, and scholarship; and the focus on both clinical and basic research in the midst of a first-rank neuroscience community.

3 ACGME-Accredited Cerebrovascular Fellowship Programs
The Department of Neurology is one of the few programs in the U.S. to provide ACGME accredited fellowship training in all 3 facets of cerebrovascular disease – vascular neurology, neurocritical care, and endovascular neuroradiology.

NINDS Research Funding & StrokeNet Research Center
Since the 1920s, the Academic Health Center at the University of Minnesota has been at the forefront of progressive research in the health sciences. Research is a critical element in the fight against neurological disease; it paves the way for the development and implementation of new therapies and provides opportunities to expand our academic mission. Understanding the root cause of neurological disorders is a hallmark of the neurology research enterprise. The department of Neurology has fostered the development of a wide range of subspecialty services provided by expert clinicians. We have interdisciplinary programs across all major subspecialties through collaborations with colleagues in the Departments of Emergency Medicine, Neurosurgery, Psychiatry, Radiology/Neuroradiology, ENT, Biomedical Engineering and Neuroscience.

The University of Minnesota, Twin Cities Department of Neurology has received a National Institute of Neurological Disorders and Stroke (NINDS) grant to serve as a Regional Coordinating Center (RCC) for StrokeNet. This network will conduct small and large clinical trials and research studies to advance acute stroke treatment, stroke prevention, and recovery and rehabilitation following a stroke. The network was launched in the Spring of 2014 and consists of 25 regional centers across the U.S., with more than 200 satellite hospitals, and teams of researchers representing every medical specialty needed for stroke care and will address the three prongs of stroke research: Prevention, Treatment and Recovery. The Regional Coordinating Centers are designed to serve as the infrastructure and pipeline for exciting new potential treatments for patients with stroke and those at risk for stroke. In addition, NIH StrokeNet will provide an educational platform for stroke physicians and clinical trial coordinators. The National Coordinating Center for NIH StrokeNet is at the University of Cincinnati.

Leader in NIH funding
The University of Minnesota College of Medicine ranks among the top 1% of NIH-funded institutions throughout the country, with nearly $250 million awarded in research grants in 2014 alone. Similarly, the Department of Neurology and the Department of Neuroscience were ranked #13 and #17, respectively, with nearly $20 million in combined research grants.

Cutting-edge Neuroscience Research
The University of Minnesota is one of only 11 institutions selected as a site to investigate the Human Connectome Project. 6 U of M investigators are contributing cutting-edge research in the understanding of the human brain, making use of the University’s Center for Magnetic Resonance Research 10.5 Tesla MRI, the largest in the world. Stroke research taking place at the U includes:

  • Impact of stroke, prevention, treatment, recovery and StrokeNet: Mustapha Ezzeddine, M.D., is an associate professor in the Department of Neurology and principal investigator at the University of Minnesota stroke regional coordinating center. Ezzeddine is primarily interested in neurocritical care and vascular neurology. He is also the Medical Director of Stroke Services at the University of Minnesota Medical Center, Fairview.
  • Using stem cells to treat stroke: Andrew Grande, M.D., is an assistant professor in the Department of Neurosurgery and Co-director of the Earl Grande Stroke and Stem Cell Laboratory. Grande is currently exploring how to use stem cells to replace and regenerate damaged neurons in the brain after a stroke that will ultimately lead to functional improvement of those neurons.
  • Advanced imaging techniques in stroke research: Wei Chen, Ph.D., professor of radiology at the Center for Magnetic Resonance Research (CMRR) is developing a variety of advanced MRI and magnetic resonance spectroscopy (MRS) imaging techniques that provide new and unique information for quantitative assessment of stroke injury, progression and recovery with better specificity.
  • Need for best practices for post-stroke care: Kamakshi Lakshminarayan, M.D., Ph.D., is an assistant professor of neurology in the University of Minnesota Medical School. Lakshminarayan’s research is working to engage with patients and their caregivers to take charge and empower them to manage their health care after a stroke. She stresses the need for a system overhaul and the establishment of a patient engagement framework on how post-stroke care should be.
  • New therapies aiding in stroke rehab: Bernadette Gillick, Ph.D., an assistant professor, and James Carey, Ph.D., professor in the University of Minnesota Medical School’s Program in Physical Therapy, are developing new forms of stroke therapies and rehab for children and adults.

 

Commitment to Academic Values and Protected Time
Noteworthy dedication to the pursuit of traditionally academic values, avoiding the present trend observed at many ‘academic’ centers that are transitioning away from their prior commitments to basic science and translational research.

Neurocritical Care Service

The Neurocritical Care Service is part of the Stroke Center at the University of Minnesota. The Stroke Center is an interdepartmental and inter-institutional program organized to build collaboration in the areas of service, education and research in cerebrovascular disease between the departments of Neurology, Neurosurgery and Radiology. Candidates will join a team of physicians practicing vascular neurology, Neurocritical care, and neurointerventions from neurology, neurosurgery and radiology. The program is currently engaged in high quality clinical and basic science research, as well as active fellowships in vascular neurology, Neurocritical care and endovascular surgical neuroradiology.

The Neurocritical Care Center is based at the University Hospital (UMMC), and includes an 8-bed Neuro ICU. The 8-bed Neuro ICU is a closed unit for Neurology patients, and an open unit for Neurosurgery patients. A team of 3 Neurointensivists provides Neurocritical care for patients with severe nervous system diseases. The Neurocritical care service provides primary intensive unit care for all neurology and neurological surgery patients and consultations for patients admitted to the Neuro ICU under other services. The Neurocritical Care Unit sees a high percentage of hemorrhagic and Ischemic Stroke, subarachnoid hemorrhage, and AVM’s, in addition to the typical disease spectrum seen in Neurocritical care.

Stroke Center

The Stroke Center at University of Minnesota Medical Center is a world-class, comprehensive stroke program providing patients the full spectrum of care. The Center has earned the Gold Seal of Approval™ from The Joint Commission for Primary Stroke Centers, recognizing the commitment to provide outstanding care to patients and the community. The stroke team of neurologists, interventional neuro radiologists, neurosurgeons and dedicated staff from University of Minnesota Physicians work together to provide state-of-the art stroke treatment, rehabilitation and stroke prevention. The team’s expertise and collaborative approach to stroke care helps address all the needs of a stroke patient and family throughout the process. This approach has proven successful: in 2014, the program reported zero 90-day mortality rate.

As a leader in the development and implementation of innovative neurologic services, the Stroke Center offers:
• 24-hour acute stroke care through our Emergency Department
• Neuro-endovascular services through a team of endovascular specialists from neurology, neurosurgery and radiology
• Neurointensive care for patients with cerebrovascular diseases
• Evaluation and follow-up care through the Stroke Center
• Full range of acute, inpatient and after-care services
• Rehabilitation through Fairview Acute Rehabilitation Center or Transitional Care unit

This combination of coordinated services and expertise makes it one of the largest and most comprehensive teams in the United States.

Department of Neurology Overview

The Department of Neurology at the University of Minnesota is led by Jerrold L. Vitek, MD, PhD, Professor and Chairman of the Department of Neurology, and nationally recognized physician/scientist from the standpoint of both non-human primate and human clinical studies on the neurophysiology of movement disorders and neuromodulation mechanisms. The Department has a long and storied tradition of committed leadership: starting from the direction of internationally-renowned A.B Baker, MD, PhD – who was instrumental in founding the American Academy of Neurology and served as its first president in 1948 – through the current Chair, Jerrold Vitek, MD, PhD, there has been a strong commitment to providing outstanding patient care, engaging in novel and impactful scientific investigations, fulfilling the academic mission of recruiting the best, brightest and most motivated applicants and supporting their transition to independent careers as neurologists and neuroscientists.

The Department of Neurology is comprised of more than 45 physician and physician scientist faculty members that provide patient care at four public teaching hospitals throughout the Twin Cities: University of Minnesota Medical Center, Fairview (UMMC), Hennepin County Medical Center (HCMC), the Minneapolis Veterans Administration Hospital (VAMC), and Regions Medical Center (Regions). Across the public teaching hospitals, the Department cares for more than 3,000 inpatient evaluations and 10,000 outpatient visits each year.

Since its inception in 1946, the Department has been dedicated to high quality clinical care and internationally recognized research oriented accomplishments, obtained in large measure due to the effective embracement of interdisciplinary/interdepartmental collaboration. Today, interdisciplinary collaboration crosses all major disciplines including Neurosurgery, Psychiatry, Pediatrics, Psychology, Pharmacy, Radiology/Neuroradiology, ENT, Biomedical Engineering and Neuroscience. The Department also collaborates with colleagues in the Center for Magnetic Resonance Research (CMRR), the Institute of Human Genetics, the Division of Epidemiology and Community Health (School of Public Health), and the Brain Sciences Center and Geriatric Research and Education Clinical Center (GRECC) at the Minneapolis VA Medical Centers. Additionally, a new program in vestibular and balance disorders is being developed and will be interdisciplinary oriented.

Neurology Teaching & Training Overview

The University of Minnesota Neurology Residency Program has been around since the 1940s when it was initially developed under the guidance of Dr. A.B. Baker, the founder of the American Academy of Neurology. Today, the 4 year Neurology Residency Program graduates 6-7 Residents per year. The Department of Neurology also boasts an impressive number of clinical fellowships in 6 sub-specialties including Clinical Neurophysiology, Stroke, Neurocritical Care and Endovascular Surgical Neuroradiology. The opportunities to develop clinical and basic research in virtually any area of interest are available at the University of Minnesota providing limitless opportunities for faculty, fellows, and residents.

Neurology Residency

The structure of the University of Minnesota’s neurology residency program enables trainees to satisfy ACGME core-competency requirements for patient care, medical knowledge, practice-based learning, interpersonal communication skills, professionalism and system-based practice. It allows for residents to acquire clinical skills, build confidence and participate in supervised research activities while satisfying their intellectual curiosity and the need to care for patients and assume responsibility for medical decision making. The residency program is designed to meet trainees’ expectations for achieving career goals, and we view such an emphasis as indispensable for the development of exceptional neurologists. The program encompasses a diverse group of hospitals — the University of Minnesota Medical Center, Fairview (UMMC); Hennepin County Medical Center (HCMC); the Minneapolis Veterans Affairs Medical Center (VAMC); North Memorial Medical Center (NMMC) and Regions Hospital — and provides residents with the experience required to manage and treat a wide range of neurologic disorders.

Vascular Neurology Fellowship

This ACGME-accredited fellowship at the University of Minnesota and affiliated hospitals provides one year of training in emergency management of stroke, neurocritical care, application of modern neuro-imaging techniques, rehabilitation and stroke prevention. As part of the Brain Attack team, the Vascular Neurology fellows participate in all stroke cases brought to the Emergency Room. Fellows also take at-home call several nights a week.

Among the significant strengths of the program are the range and depth of the clinical experience provided at several teaching hospitals (Hennepin County Medical Center and University of Minnesota Medical Center-Fairview for the Vascular Neurology program); the devotion of the full-time faculty at each of these hospitals to teaching, patient care, and scholarship; and the focus on both clinical and basic research in the midst of a first-rank neuroscience community.

The University of Minnesota program is comprised of internationally known stroke specialists as well as interventionalists who have pioneered several endovascular techniques. A very active epidemiological, clinical, and basic research program focused on cerebrovascular diseases provides opportunities for advanced training.

Stroke Faculty:
• David C. Anderson, M.D.(UMMC and HCMC), Program Director
• Scott Bundlie, M.D. (HCMC)
• Mustapha Ezzeddine, M.D. (HCMC and UMMC)
• Kamakshi Lakshminarayan, M.D., Ph.D. (HCMC and UMMC)

 

UMMC Fairview

 

Critical Care Fellowship

The Department of Neurology offers a one-to-two year fellowship in Neurocritical Care based at Hennepin County Medical Center and University of Minnesota Medical Center, Fairview. This program is designed to provide comprehensive training in the care and management of critically-ill neuroscience patients. General critical care experience is complemented by rotations in other intensive care units. Close clinical collaboration with the vascular and endovascular programs as well as the neurosurgical service is expected.

Neurocritical Care Faculty:
• Mustapha Ezzeddine, M.D., Program Director 
• David C. Anderson, M.D.
• Kamakshi Lakshminarayan, M.D., Ph.D.
• Robert Taylor, M.D.
• Ramachandra Tummala, M.D.

Endovascular Surgical Neuroradiology (ESN) Fellowship

This “NeuroIntervention” fellowship at the University of Minnesota and affiliated hospitals provides two years of training emphasizing endovascular procedures, including catheter-based thrombolysis, embolization, and stent placement for various cerebrovascular diseases. The program faculty includes internationally known interventionalists who have pioneered several endovascular techniques.

NeuroIntervention Faculty:
• Andrew Grande, M.D.
• Bharathi Jagadeesan, M.D.
• Robert Taylor, M.D.
• Ramachandra Tummala, M.D., Program Director

University of Minnesota Research

The University of Minnesota is ranked in the top 1% of US Institutions in terms of total NIH funding, thus demonstrating a clear institution wide commitment to research. Highlighted below are specific research programs at the University of Minnesota which create powerful points of leverage for neurologists with near and longer term clinical and translational research.

Human Connectome Project (HCP)

The Human Connectome Project, or HCP, has brought the combined brainpower of 36 investigators — including six from the University of Minnesota —from 11 different institutions to bear on the challenges of understanding the human brain.

In 2010, the National Institutes of Health awarded almost $40 million in grants to support brain mapping and imaging research efforts by two consortia. The largest grant — $30 million over five years — was awarded to a consortium led by Washington University in St. Louis and the University of Minnesota.

The WU-Minn. consortium was tasked with optimizing MRI scanners, related technologies, and data acquisition methods to capture the most advanced images ever of the brain’s anatomical wiring (using diffusion-weighted MRI) and its activity (using functional MRI or fMRI), both in resting state and while the subject is performing various tasks.
In total, the WU-Minn Connectome Project will acquire high-resolution MRI brain scans from 1,200 healthy adults. This group will include 300 sets of four siblings — each set consisting of a pair of twins and two non-twin siblings. In addition to brain scans, the project will collect genetic information and behavioral data for each subject. Washington University is conducting the majority of the scans, but the University of Minnesota will conduct even higher-resolution scans — both 7T and 10.5T — of a subset of the larger group. The researchers believe that by comparing these different scans of the same individuals, they will be able to learn more about how various parts of the brain interact.

A second consortium, led by Massachusetts General Hospital/Harvard University and UCLA, received an $8.5 million grant to perform similar studies using diffusion MRI technology for imaging the brain’s structural connections. Both research groups will make their data freely available to neuroscientists and other researchers around the world. The WU-Minn. consortium has begun releasing data from the scans acquired to date.

Center for Magnetic Resonance Research (CMRR)

Established in 1991, the CMRR is an interdepartmental and interdisciplinary research laboratory that provides state-of-the-art instrumentation, expertise, and infrastructure to carry out biomedical research utilizing the unique capabilities provided by high field MRI and MRS methodology.

The central aim of the research conducted in CMRR is to non-invasively obtain functional, physiological, and biochemical information in intact biological systems, and use this capability to probe biological processes in health and disease. Which focuses on the development of unique magnetic resonance (MR) imaging and spectroscopy methodologies and instrumentation for the acquisition of structural, functional, and biochemical information non-invasively in humans, and utilizing this capability to investigate organ function in health and disease.

Funded by the NIH as a Biotechnology Research Resource for High field Magnetic Resonance Imaging and Spectroscopy, and supported by numerous governmental and private foundations, CMRR core faculty have made significant and pioneering contributions in biological applications of magnetic resonance techniques, and possess unique expertise in very high field uses of this methodology. CMRR faculty conducts research in a variety of areas including:
• High field functional brain mapping in humans; methodological developments, mechanistic studies, and neuroscience applications
• Metabolism, bioenergetics, and perfusion studies of human pathological states (tumors, obesity, diabetes, hepatic encephalopathy, cystic fibrosis, and psychiatric disorders)
• Cardiac bioenergetics under normal and pathological conditions
• Automated magnetic field shimming methods that are critical for spectroscopy and ultrafast imaging at high magnetic fields
• Development of high field magnetic resonance imaging and spectroscopy techniques for anatomic, physiologic, metabolic, and functional studies in humans and animal models
• Radiofrequency (RF) pulse design based on adiabatic principles
• Development of magnetic resonance hardware for high fields (e.g. RF coils, pre-amplifiers, digital receivers, phased arrays, etc.)
• Development of software for data analysis and display for functional brain mapping.

Resources include:

  • 10.5 Tesla / 89 cm Bore system for human studies (world’s largest)
  • 16.4 Tesla for animal model studies
  • 9.5 (2) Tesla for animal model studies
  • 7 Tesla (shielded MR System for Human Studies; eye tracking)
  • Cyclotron – Siemens PETNET
  • 17.0 Tesla 5cm Vertical Bore
  • 4 Tesla for human studies
  • Siemens Inveon preclinical microPET/CT
  • 3 Tesla (multiple, w/advanced imaging)

17 Tesla 5 cm Vertical Bore


Neuromodulation Research Center and Lab (NRCL)

The NRCL develops multi-scale computational neuron models to further understanding of the biophysical and physiological mechanisms of neuromodulation. In partnership with the Minnesota Supercomputing Institute, the NRCL couples finite element models of electric fields generated in neural tissue with computational neuron models built from sets of mathematical equations that replicate the biophysical properties of membrane and synapse dynamics.

The NRCL also investigates the therapeutic mechanisms of neuromodulation experimentally through multi-channel electrophysiological and neurochemical techniques in animal models of movement disorders. The NRCL is particularly interested to determine how neurons encoding movement are modulated during deep brain stimulation, how stimulation at different therapeutic efficacies influences these neurons, and how the modulation of neuronal firing patterns changes during chronic stimulation.

The NRCL is developing new types of implants and stimulation strategies that are inspired by the underlying neuroscience. The NRCL evaluates these technologies with the goal of leveraging industrial partnerships to translate these therapies from the laboratory to the clinic.

Dr. Jerrold Vitek, M.D. PhD, Professor and Chair of Neurology directs a large interdisciplinary neuromodulation research program at the NRCL which is primarily centered on understanding the pathophysiology of movement disorders such as Parkinson’s disease and dystonia as well as the mechanisms underlying the therapeutic effect of deep brain stimulation.

Clinical and Translational Science Institute (CTSI)

The CTSI at the University of Minnesota is supported through the NIH Clinical and Translational Science Award (CTSA) program.
The institute is one of approximately 60 medical research institutions working together to improve the way clinical and translational research is conducted nationwide, enhancing its efficiency and quality.

The CTSA consortium aims to accelerate the process of translating laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers.

Well positioned to support development of K grants.

The CTSI has five main offices, including:
• Office of Discovery and Translation: Supports researchers in the early stages of translational research by funding projects, offering consultations, and connecting investigators to translational technologies and experts.
• Clinical Translational Research Services: Provides comprehensive services and support for planning, implementing, conducting, and analyzing clinical studies.
• Populations and Community Engagement: Enables investigators and the community to collaborate on research by matching partners, providing expert consultations, funding projects, and offering resources, tools, and training.
• Biomedical Informatics: Drives the integration of clinical data across the University and Fairview, and gives researchers a one-stop-shop for the data, tools, and information technologies they need to accelerate their research.
• Education, Training, and Research Career Development (CTSI-Ed): Advances the research careers of faculty, staff, and students through education, training, and career development programming.

 

Minneapolis-St. Paul – Location Specifics

The University of Minnesota is located in the Twin Cities of Minneapolis and St. Paul, the birth place and headquarters of the American Academy of Neurology (AAN). Four key attributes sets the Minneapolis-Saint Paul region apart: a resilient, diverse economy anchored by 17 Fortune 500 companies, a penchant for innovation, a highly educated workforce – one of the best in the nation and an outstanding quality of life.

The Minneapolis-Saint Paul area is cosmopolitan at its heart and small town along its perimeter. The Twin Cities is the 16th largest metro area in the US, with a population of approximately 3.4 million people. It is the 2nd largest economic center in the Midwest, behind Chicago, and the second largest medical device manufacture center in North America. Minneapolis proper contains the 5th highest concentration of Fortune 500 companies in the country. The presence of the corporate headquarters for companies such as Target, US Bancorp, Xcel Energy and Ameriprise Financial provide a growing economy with great job opportunities for a candidate’s spouse or family. Additionally, an exciting arts and music scene, exceptional shopping, award-winning restaurants, wineries and craft breweries, and distinctive accommodations can be found throughout the area. Outdoor enthusiasts find plenty to do – even when LittleToadLake_Minnesota_sunsettemperatures dip, the variety of fun outdoor adventures does not. Sports fans cheer on their favorite team year-around. Big city bustle or small town charm, anyone can find the activity that suits them in the Minneapolis – Saint Paul Area.

Forbes ranks the Minneapolis-St. Paul region as follows:
• #17 Best Places for Business and Careers
• #18 in Education

How to apply

In an overall effort to identify the most qualified potential candidates, the University of Minnesota has retained the services of Academic Med Physician Recruiters. If you have interest or questions regarding this position please contact Soto Nikolopoulos, the Search Consultant overseeing the recruitment for this opportunity (214.396.6103). You may also submit your CV to Mr. Nikolopoulos via email (Soto.Nikolopoulos@academic-med.com); he is fully equipped to answer any questions that you may have.